Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | PLG | P00747 | 2/20 | 0.50 |
| ▸ | KLK1 | P06870 | 2/20 | 0.50 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.50 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11288797 | 0.86 | HSP90AB1 (0.64) | HSP90AA1HSP90AB1SMN1; SMN2LMNAHTT | |
| SCHEMBL11345490 | 0.84 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1SMN1; SMN2LMNAHTT | |
| SCHEMBL11343595 | 0.83 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1SMN1; SMN2LMNAHTT | |
| SCHEMBL432204 | 0.81 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1SMN1; SMN2LMNAHTT | |
| SCHEMBL11340585 | 0.81 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1SMN1; SMN2LMNAHTT | |
| SCHEMBL11346040 | 0.80 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1SMN1; SMN2LMNAHTT | |
| SCHEMBL10488407 | 0.80 | LMNA (0.79) | HSP90AA1HSP90AB1SMN1; SMN2LMNAHTT | |
| SCHEMBL11295395 | 0.80 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1SMN1; SMN2LMNAHTT | |
| SCHEMBL11347012 | 0.80 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1SMN1; SMN2LMNAHTT | |
| SCHEMBL134234 | 0.79 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1HTTALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006549-A | Antiinflammatory agents | MERCK & CO., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0399773-A1 | Novel 7-aroyl-4-hydroxy-3-methyl benzolfurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase | MERCK & CO. INC. (US) | 1990-11-28 | — | — | EP | disclosed |
| EP-0104018-A2 | Benzopyran, benzothiapyran and quinoline compounds and pharmaceutical compositions containing them | FISONS plc (GB) | 1984-03-28 | — | — | EP | disclosed |