Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL986910 | 1.00 | ALDH1A1 (0.52) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL986672 | 0.86 | ALDH1A1 (0.52) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL986674 | 0.86 | ALDH1A1 (0.52) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL13731837 | 0.85 | ALDH1A1 (0.38) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL985329 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL1232051 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL986854 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL986838 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL1231031 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL2833778 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TSHRKDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111138343-A | Tris (2, 2,6, 6-tetramethyl piperidinol) citrate and preparation method thereof | 宿迁联盛科技股份有限公司 | 2020-05-12 | — | — | CN | claimed |
| US-7862746-B2 | Stabilization of natural composites | BASF SE. (DE) | 2011-01-04 | — | — | US | claimed |
| WO-2006087269-A1 | STABILIZATION OF NATURAL COMPOSITES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-08-24 | — | — | WO | claimed |
| US-20060183821-A1 | Stabilization of natural composites | CIBA CORPORATION | 2006-08-17 | — | — | US | claimed |
| CN-111138343-A | Tris (2, 2,6, 6-tetramethyl piperidinol) citrate and preparation method thereof | 宿迁联盛科技股份有限公司 | 2020-05-12 | — | — | CN | disclosed |
| CN-111138343-A | Tris (2, 2,6, 6-tetramethyl piperidinol) citrate and preparation method thereof | 宿迁联盛科技股份有限公司 | 2020-05-12 | — | — | CN | disclosed |
| CN-111138343-A | Tris (2, 2,6, 6-tetramethyl piperidinol) citrate and preparation method thereof | 宿迁联盛科技股份有限公司 | 2020-05-12 | — | — | CN | disclosed |
| US-7862746-B2 | Stabilization of natural composites | BASF SE. (DE) | 2011-01-04 | — | — | US | disclosed |
| WO-2006087269-A1 | STABILIZATION OF NATURAL COMPOSITES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-08-24 | — | — | WO | disclosed |
| US-20060183821-A1 | Stabilization of natural composites | CIBA CORPORATION | 2006-08-17 | — | — | US | disclosed |