Citric Acid

Citric Acid

SCHEMBL2833778

CC1(C)CC(=O)CC(C)(C)N1O.O=C(O)CC(O)(CC(=O)O)C(=O)O

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.34
ALDH1A1 P00352 4/20 0.48
KDM4E B2RXH2 4/20 0.38
LMNA P02545 3/20 0.38
TSHR P16473 3/20 0.38
MAPT P10636 2/20 0.38
ALOX15 P16050 2/20 0.38
SLC13A5 Q86YT5 7/20 0.34
CYP2D6 P10635 3/20 0.34
KMT2A Q03164 2/20 0.34
CYP1A2 P05177 2/20 0.34
HMGCR P04035 1/20 0.31
CHRM1 P11229 1/20 0.31
TBXA2R P21731 1/20 0.31
ADRA1A P35348 1/20 0.31
HIF1A Q16665 2/20 0.31
GAA P10253 1/20 0.31
CYP2C19 P33261 1/20 0.31
CYP3A4 P08684 1/20 0.30
NFKB1 P19838 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL1231031 1.00 ALDH1A1 (0.48) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL1232051 1.00 ALDH1A1 (0.48) ALDH1A1KDM4ELMNATSHRMAPT
SCHEMBL1232056 0.81 ALDH1A1 (0.42) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL986910 0.80 ALDH1A1 (0.52) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL986909 0.80 ALDH1A1 (0.52) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL985329 0.77 ALDH1A1 (0.48) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL986838 0.77 ALDH1A1 (0.48) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL986854 0.77 ALDH1A1 (0.48) ALDH1A1KDM4ELMNATSHRMAPT
Acetic Acid SCHEMBL986789 0.77 KMT2A (0.40) ALDH1A1MAPTALOX15KMT2AMEN1
Citric Acid SCHEMBL7531324 0.76 ALDH1A1 (0.47) ALDH1A1KDM4ELMNATSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2464739-B1 METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES BASF SE (DE) 2016-01-13 EP claimed
US-8859235-B2 Methods in cell cultures, and related inventions, employing certain additives BASF SE (DE) 2014-10-14 US claimed
EP-1896550-B1 STABILIZED ELECTROCHROMIC MEDIA BASF SE (DE) 2013-08-14 EP claimed
EP-1680541-B1 STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS BASF SE (DE) 2012-12-19 EP claimed
CN-1902353-B Stabilized body care products, household products, textiles and fabrics CIBA SPEC CHEM CORP 2012-08-15 CN claimed
US-20120164162-A1 METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES BASF SE (DE) 2012-06-28 US claimed
US-7718096-B2 Stabilized electrochromic media CIBA SPECIALTY CHEMICALS CORPORATION (US) 2010-05-18 US claimed
EP-1499286-B1 STABILIZED BODY CARE PRODUCTS AND HOUSEHOLD PRODUCTS BASF SE (DE) 2010-04-07 EP claimed
EP-1896550-A1 STABILIZED ELECTROCHROMIC MEDIA Ciba Specialty Chemicals Holding Inc. (CH) 2008-03-12 EP claimed
US-20070079446-A1 Stabilized body care products, household products, textiles and fabrics CIBA SPECIALTY CHEMICALS CORP. 2007-04-12 US claimed
US-20070002423-A1 Stabilized electrochromic media CIBA SPECIALTY CHEMICALS CORP. 2007-01-04 US claimed
EP-1680541-A2 STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS Ciba SC Holding AG (CH) 2006-07-19 EP claimed
US-20050220727-A1 Stabilized body care products, household products, textiles and fabrics CIBA CORPORATION 2005-10-06 US claimed
CN-1649566-A Stabilized body care products, household products, textiles and fabrics CIBA SC HOLDING AG (CH) 2005-08-03 CN claimed
WO-2005042828-A2 STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2005-05-12 WO claimed
EP-1499286-A1 STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS Ciba SC Holding AG (CH) 2005-01-26 EP claimed
WO-2003103622-A1 STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-12-18 WO claimed
US-6500303-B1 DERIVATIVES OF 1-OXYL-2,2,6,6-TETRAMETHYL-PIPERIDIN-4-OL; PROTECTION FROM ULTRAVIOLET, FLUORESCENT AND SUN LIGHT EXPOSURE CIBA SPECIALTY CHEMICALS CORPORATION 2002-12-31 US claimed
US-20020124980-A1 Inhibition of pulp and paper yellowing using nitroxides, hydroxylamines and other coadditives SELTZER RAYMOND R (US) 2002-09-12 US claimed
US-6254724-B1 STABILIZING AMOUNT OF A HINDERED AMINE COMPOUND SELECTED DERIVATIVES OF 1-OXYL-2,2,6,6-TETRAMETHYL-PIPERIDIN-4-OL OR WHICH ARE THEIR HYDROXYLAMINE SALTS CIBA SPECIALTY CHEMICALS CORPORATION 2001-07-03 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070079446-A1 Stabilized body care products, household products, textiles and fabrics CUTA, NISCH, DSC1 MEN1 2500/4885ALDH1A1 1122/4885KDM4E 1682/4885
US-20050220727-A1 Stabilized body care products, household products, textiles and fabrics CUTA, DHRS9, DSC1 MEN1 2460/4885ALDH1A1 816/4885KDM4E 1585/4885
US-20120164162-A1 METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES BBOX1, NEFM, NQO1 MEN1 3694/4885ALDH1A1 152/4885KDM4E 715/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.