Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 3/20 | 0.59 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.56 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726237 | 0.98 | SIGMAR1 (0.60) | SIGMAR1HTR1AKCNA3 | |
| SCHEMBL14601668 | 0.83 | SIGMAR1 (0.60) | SIGMAR1HTR1AKCNA3 | |
| SCHEMBL5541146 | 0.83 | SIGMAR1 (0.60) | SIGMAR1HTR1AKCNA3 | |
| SCHEMBL9726233 | 0.83 | SIGMAR1 (0.61) | SIGMAR1HTR1AKCNA3 | |
| SCHEMBL9867159 | 0.83 | SIGMAR1 (0.60) | SIGMAR1HTR1AKCNA3 | |
| SCHEMBL6162058 | 0.83 | SIGMAR1 (0.60) | SIGMAR1HTR1AKCNA3 | |
| Hydrochloric Acid SCHEMBL9868303 | 0.81 | SIGMAR1 (0.59) | SIGMAR1HTR1AKCNA3 | |
| SCHEMBL256663 | 0.81 | SIGMAR1 (0.63) | SIGMAR1HTR1AKCNA3 | |
| SCHEMBL7297566 | 0.81 | SIGMAR1 (0.63) | SIGMAR1HTR1AKCNA3 | |
| SCHEMBL5544346 | 0.81 | SIGMAR1 (0.63) | SIGMAR1HTR1AKCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4999355-A | Antiserotonine agents | RHONE-POULENC (FR) | 1991-03-12 | — | — | US | disclosed |