SCHEMBL9869257

SCHEMBL9869257

Cc1nc2cnccc2n1-c1ccc(CNc2ccccc2N)cc1

nearest known ligand 0.58

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
RPS6KA5 O75582 2/20 0.43
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
ADRA2C P18825 1/20 0.40
DRD1 P21728 1/20 0.40
ALDH1A1 P00352 1/20 0.40
MAPK1 P28482 1/20 0.39
HTT P42858 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9525557 0.78 MAPK1 (0.51) RPS6KA5MEN1KMT2ADRD1MAPK1
SCHEMBL9524857 0.77 RPS6KA5 (0.61) RPS6KA5DRD1
SCHEMBL7774816 0.76 DRD1 (0.49) RPS6KA5MEN1KMT2ADRD1
SCHEMBL16168685 0.76 MEN1 (0.53) RPS6KA5MEN1KMT2ADRD1
SCHEMBL540767 0.75 MAPK1 (0.67) RPS6KA5DRD1ALDH1A1MAPK1HTT
SCHEMBL9524646 0.75 TP53 (0.45) MEN1KMT2A
SCHEMBL7774814 0.73 TNF (0.59) MAPK1HTT
SCHEMBL10388437 0.73 DRD1 (0.47) RPS6KA5MEN1KMT2ADRD1
SCHEMBL10054042 0.73 DRD1 (0.53) DRD1MAPK1HTT
SCHEMBL9526774 0.72 PDPK1 (0.51) RPS6KA5DRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1991017162-A1 IMIDAZOPYRIDINE PAF ANTAGONISTS PFIZER LIMITED (GB) 1991-11-14 WO disclosed