Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869842 | 0.89 | KMT2A (0.68) | PKML3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8630241 | 0.85 | L3MBTL1 (1.00) | PKML3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3421265 | 0.79 | L3MBTL1 (0.79) | PKML3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4021262 | 0.77 | KDR (0.64) | PKML3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4017666 | 0.75 | L3MBTL1 (0.65) | PKML3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9661173 | 0.75 | PKM (0.68) | PKML3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL18795683 | 0.73 | L3MBTL1 (0.64) | PKML3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13242893 | 0.73 | L3MBTL1 (0.76) | PKML3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4018474 | 0.72 | SMN1; SMN2 (0.65) | PKML3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9661093 | 0.72 | L3MBTL1 (0.71) | PKML3MBTL1KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006532-A | Enzyme inhibitor; antiinflammatory agents | MERCK & CO. INC., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4904672-A | Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4767766-A | Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1988-08-30 | — | — | US | disclosed |