Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.70 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869970 | 0.84 | PRMT5 (0.51) | PRMT5WDR77KDM4ETSHRCYP2D6 | |
| SCHEMBL15833543 | 0.83 | PRMT5 (1.00) | PRMT5WDR77SMN1; SMN2KMT2A | |
| SCHEMBL7047201 | 0.80 | CYP2D6 (0.52) | PRMT5WDR77KDM4ETSHRCYP2D6 | |
| SCHEMBL9839972 | 0.79 | TSHR (0.74) | PRMT5WDR77KDM4ETSHRCYP2D6 | |
| SCHEMBL9838876 | 0.79 | TSHR (0.74) | PRMT5WDR77KDM4ETSHRCYP2D6 | |
| SCHEMBL9838885 | 0.79 | TSHR (0.74) | PRMT5WDR77KDM4ETSHRCYP2D6 | |
| SCHEMBL30972154 | 0.76 | LTA4H (0.54) | — | |
| SCHEMBL30972142 | 0.74 | LTA4H (0.52) | TSHR | |
| SCHEMBL25010831 | 0.72 | KDM4E (1.00) | KDM4ETSHRCYP2D6HIF1AMAPK1 | |
| SCHEMBL11537591 | 0.72 | KDM4E (1.00) | KDM4ETSHRCYP2D6HIF1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4999361-A | Cardiovascular disorders, blood vessel relaxants | BOEHRINGER MANNHEIM GMBH (DE) | 1991-03-12 | — | — | US | disclosed |
| EP-0330940-A2 | Trisubstituted amines, process for their preparation and pharmaceutical preparations containing these compounds | Roche Diagnostics GmbH (DE) | 1989-09-06 | — | — | EP | disclosed |