Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.51 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869323 | 0.84 | PRMT5 (0.70) | PRMT5WDR77GAAHTTKDM4E | |
| SCHEMBL9838672 | 0.79 | TSHR (0.51) | PRMT5WDR77GAAHTTKDM4E | |
| SCHEMBL9869891 | 0.79 | TSHR (0.51) | PRMT5WDR77GAAHTTKDM4E | |
| SCHEMBL30972154 | 0.76 | LTA4H (0.54) | LTA4HPTGS2 | |
| SCHEMBL30972142 | 0.74 | LTA4H (0.52) | TSHRLTA4HPTGS2 | |
| SCHEMBL7271333 | 0.72 | KDM4E (0.67) | KDM4ETSHRCYP2D6HIF1AMAPK1 | |
| SCHEMBL11538263 | 0.71 | TSHR (0.68) | KDM4ETSHRCYP2D6HIF1AMAPK1 | |
| SCHEMBL493397 | 0.70 | HRH1 (0.52) | KDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8267907 | 0.70 | GRIN2D (0.49) | ALDH1A1CYP1A2CYP2C19KMT2A | |
| SCHEMBL2608863 | 0.70 | ALDH1A1 (0.47) | PRMT5WDR77HTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4999361-A | Cardiovascular disorders, blood vessel relaxants | BOEHRINGER MANNHEIM GMBH (DE) | 1991-03-12 | — | — | US | disclosed |
| EP-0330940-A2 | Trisubstituted amines, process for their preparation and pharmaceutical preparations containing these compounds | Roche Diagnostics GmbH (DE) | 1989-09-06 | — | — | EP | disclosed |