Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 7/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10470690 | 0.77 | MAOA (0.50) | SLC22A12SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL9869361 | 0.77 | MAOB (0.56) | SLC22A12SMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL1024806 | 0.74 | KMT2A (0.51) | SLC22A12SLC22A6SMN1; SMN2MEN1KMT2A | |
| SCHEMBL31083321 | 0.72 | SLC22A12 (0.51) | SLC22A12MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL1024738 | 0.71 | CLK1 (0.44) | SLC22A12SMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL29530507 | 0.71 | CLK1 (0.44) | SLC22A12SMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL4538464 | 0.70 | CA12 (0.53) | SLC22A12SMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL4821326 | 0.70 | SMN1; SMN2 (0.43) | HSD11B1SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL20738370 | 0.70 | IDO1 (0.48) | HSD11B1SMN1; SMN2GAATSHR | |
| SCHEMBL31649996 | 0.69 | CA12 (0.50) | SMN1; SMN2CYP1A2CYP3A4GAACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006532-A | Enzyme inhibitor; antiinflammatory agents | MERCK & CO. INC., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4904672-A | Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4767766-A | Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1988-08-30 | — | — | US | disclosed |