Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25252466 | 0.83 | MAOB (0.54) | MAOBMAOAPPARGNCOA2NCOA1 | |
| SCHEMBL30991734 | 0.83 | MAOB (0.54) | MAOBMAOAPPARGNCOA2NCOA1 | |
| SCHEMBL10470690 | 0.81 | MAOA (0.50) | MAOBMAOAPPARGNCOA2NCOA1 | |
| SCHEMBL9869356 | 0.77 | SLC22A12 (0.48) | MEN1KMT2ATSHRCYP3A4NPC1 | |
| SCHEMBL17080256 | 0.76 | MAOB (0.63) | MAOBMAOAALDH1A1TDP1L3MBTL1 | |
| SCHEMBL29070081 | 0.76 | MAOB (0.63) | MAOBMAOAALDH1A1TDP1L3MBTL1 | |
| SCHEMBL9869016 | 0.75 | FFAR1 (0.50) | GSK3AGSK3BTSHRMAPTKDM4E | |
| SCHEMBL1024806 | 0.75 | KMT2A (0.51) | NCOA3ALDH1A1TDP1L3MBTL1MEN1 | |
| SCHEMBL9869415 | 0.74 | LMNA (0.53) | ALDH1A1L3MBTL1GSK3AGSK3BMEN1 | |
| SCHEMBL31294262 | 0.74 | MAOB (0.67) | MAOBMAOAPPARGNCOA2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006532-A | Enzyme inhibitor; antiinflammatory agents | MERCK & CO. INC., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4904672-A | Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4767766-A | Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1988-08-30 | — | — | US | disclosed |