SCHEMBL9869459

SCHEMBL9869459

Cc1cc([N+](=O)[O-])c(Cl)cc1NC(=O)C1(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C1(F)F

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.41
SLC9A1 P19634 1/20 0.41
CXCR2 P25025 1/20 0.40
MAPT P10636 4/20 0.39
NPSR1 Q6W5P4 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.37
MEN1 O00255 1/20 0.37
S1PR4 O95977 1/20 0.37
ALDH1A1 P00352 1/20 0.37
OPRK1 P41145 1/20 0.37
HTT P42858 1/20 0.37
RAB9A P51151 1/20 0.37
KMT2A Q03164 1/20 0.37
PAX8 Q06710 1/20 0.37
GPR55 Q9Y2T6 1/20 0.37
PPIA P62937 1/20 0.36
CHEK1 O14757 1/20 0.36
PKM P14618 1/20 0.36
TNF P01375 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10870779 0.88 CXCR2 (0.42) LMNASLC9A1CXCR2MAPTMEN1
SCHEMBL10363064 0.88 CXCR2 (0.42) LMNASLC9A1CXCR2MAPTMEN1
SCHEMBL2972082 0.79 SLC9A1 (0.60) LMNASLC9A1CXCR2MAPTNPSR1
SCHEMBL10364662 0.76 MAPT (0.56) LMNAMAPTNPSR1L3MBTL1SMN1; SMN2
SCHEMBL10363778 0.76 MEN1 (0.58) LMNAMAPTNPSR1SMN1; SMN2MEN1
SCHEMBL10363567 0.76 HTT (0.56) LMNAMAPTL3MBTL1SMN1; SMN2MEN1
SCHEMBL10363566 0.76 ALDH1A1 (0.59) LMNAMAPTSMN1; SMN2ALDH1A1HTT
SCHEMBL10364383 0.76 MEN1 (0.45) LMNAMAPTNPSR1L3MBTL1SMN1; SMN2
SCHEMBL10362720 0.76 MAPT (0.48) LMNAMAPTNPSR1L3MBTL1ALDH1A1
SCHEMBL10364603 0.76 ALDH1A1 (0.46) MAPTNPSR1SMN1; SMN2ALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4992471-A Fluorinated carboxanilide LILLY INDUSTRIES LIMITED (GB) 1991-02-12 US disclosed
EP-0201194-B1 DIABROTICA LARVICIDAL AGENTS ELI LILLY AND COMPANY (US) 1990-10-31 EP disclosed
EP-0201193-B1 CARBOXANILIDES AIR PRODUCTS AND CHEMICALS, INC. (US) 1990-10-24 EP disclosed
EP-0238351-A2 Molluscicides LILLY INDUSTRIES LIMITED (GB) 1987-09-23 EP disclosed
EP-0201194-A2 Diabrotica larvicidal agents ELI LILLY AND COMPANY (US) 1986-11-12 EP disclosed
EP-0201193-A2 Carboxanilides AIR PRODUCTS AND CHEMICALS, INC. (US) 1986-11-12 EP disclosed