Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13039534 | 0.78 | ALDH1A1 (0.54) | KDM4EIDO1MEN1KMT2AMAPT | |
| SCHEMBL27908152 | 0.78 | KDM4E (0.47) | KDM4EIDO1MEN1KMT2AMAPT | |
| SCHEMBL1189639 | 0.78 | ALDH1A1 (0.54) | KDM4EIDO1MEN1KMT2AMAPT | |
| SCHEMBL1172409 | 0.74 | MAPT (0.52) | MEN1KMT2AMAPTGAAHTT | |
| SCHEMBL3378202 | 0.74 | MAPT (0.48) | IDO1MEN1KMT2AMAPTGAA | |
| SCHEMBL30675253 | 0.74 | RAPGEF4 (0.61) | IDO1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL392473 | 0.74 | RAPGEF4 (0.61) | IDO1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL9870952 | 0.74 | MEN1 (0.55) | KDM4EIDO1MEN1KMT2AMAPT | |
| SCHEMBL5901382 | 0.74 | MEN1 (0.46) | KDM4EIDO1MEN1KMT2AMAPT | |
| SCHEMBL3483051 | 0.72 | ALDH1A1 (0.40) | KDM4EIDO1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5025034-A | Thromboxane inhibitors | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1991-06-18 | — | — | US | claimed |
| US-4945106-A | Prostaglandins | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1990-07-31 | — | — | US | claimed |
| US-4596823-A | Prostaglandins | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1986-06-24 | — | — | US | claimed |
| EP-0043292-B1 | PROSTAGLANDINS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1986-01-15 | — | — | EP | claimed |
| CN-108699053-B | 4-hydroxy-2-phenyl-1, 3-thiazol-5-yl methanone derivatives as TRPM8 antagonists | 东佩制药股份公司 | 2022-01-14 | — | — | CN | disclosed |
| CN-108699053-A | 4- hydroxyl -2- phenyl -1,3- thiazole -5- base ketone derivatives as TRPM8 antagonists | 东佩制药股份公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-106660975-A | 2-aryl-4-hydroxy-1, 3-thiazole derivatives as TRPM 8-inhibitors for the treatment of neuralgia, pain, COPD and asthma | 东佩制药股份公司 | 2017-05-10 | — | — | CN | disclosed |