Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30365989 | 1.00 | PKM (0.56) | PKMHTR2BPOLBKMT2AKDM4E | |
| SCHEMBL16349536 | 0.92 | PARP1 (0.59) | PKMHTR2BPOLBKMT2AKDM4E | |
| SCHEMBL17533943 | 0.92 | PARP1 (0.59) | PKMHTR2BPOLBKMT2AKDM4E | |
| SCHEMBL6883705 | 0.91 | PKM (0.62) | PKMHTR2BKMT2APARP1 | |
| SCHEMBL18781842 | 0.88 | HTR2B (0.56) | PKMHTR2BPOLBKDM4E | |
| SCHEMBL666433 | 0.83 | PARP1 (0.60) | PKMHTR2BPOLBPARP1 | |
| SCHEMBL9869376 | 0.83 | HTR2B (0.60) | PKMHTR2BPOLBKMT2AKDM4E | |
| SCHEMBL662575 | 0.82 | PARP1 (0.60) | PKMHTR2BPOLBKMT2AKDM4E | |
| SCHEMBL9870915 | 0.81 | HTR2B (0.56) | PKMHTR2BPOLBKDM4EPARP1 | |
| SCHEMBL22112979 | 0.81 | KDM4E (0.61) | POLBKMT2AKDM4EPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5063228-A | 4-(substitutedaminoethyl)-3,4-dihydro-2-alkylpyrimido[1,6-a]benzimidazol-1(2H)-ones as antiarrhythmic agents | A. H. ROBBINS COMPANY, INCORPORATED (US) | 1991-11-05 | — | — | US | disclosed |