Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870196 | 0.83 | PDE4B (0.56) | PDE4BPDE4D | |
| SCHEMBL8578894 | 0.82 | ACHE (0.42) | TP53ALOX15TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL9872416 | 0.80 | PDE4B (0.59) | PDE4BPDE4DMAPK1 | |
| SCHEMBL9870727 | 0.76 | LMNA (0.53) | PDE4BPDE4D | |
| SCHEMBL9871473 | 0.75 | PDE4B (0.55) | PDE4BPDE4D | |
| SCHEMBL9871070 | 0.74 | PDE4B (0.57) | PDE4BPDE4D | |
| SCHEMBL9752566 | 0.72 | PDE4B (0.58) | PDE4BPDE4DACP1 | |
| SCHEMBL9752995 | 0.71 | PDE4B (0.60) | PDE4BPDE4D | |
| SCHEMBL9870693 | 0.71 | PDE4B (0.58) | PDE4BPDE4DACP1 | |
| SCHEMBL9752783 | 0.70 | PDE4B (0.49) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756501-A | USEFUL FOR TREATING ALZHIMER'S DISEASE, DOWN'S SYNDROM AND PARKINSON'S DISEASE INVOLVING HYPOFUNCTION OF ACETYLCHOLINE IN MAMMAL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |