Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.50 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.50 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.50 |
| ▸ | GCGR | P47871 | 14/20 | 0.48 |
| ▸ | FABP3 | P05413 | 1/20 | 0.43 |
| ▸ | FABP4 | P15090 | 1/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27525559 | 0.83 | PRKAA2 (0.51) | DPP4DPP8DPP9GCGRFABP3 | |
| SCHEMBL2647574 | 0.82 | PRKAA2 (0.47) | DPP4DPP8DPP9GCGRFABP4 | |
| SCHEMBL8877956 | 0.75 | DHODH (0.53) | FABP3FABP4FABP5DHODH | |
| SCHEMBL8364028 | 0.75 | DHODH (0.48) | GCGRDHODH | |
| SCHEMBL9872202 | 0.74 | ADORA3 (0.42) | DPP4DPP8DPP9GCGRFABP3 | |
| SCHEMBL8878718 | 0.74 | GCGR (0.54) | GCGRDHODHPRKAA2 | |
| SCHEMBL5014341 | 0.72 | KDM4E (0.42) | DPP4DPP8DPP9DHODH | |
| SCHEMBL2646810 | 0.72 | PRKAA2 (0.47) | GCGRPRKAA2 | |
| SCHEMBL9872399 | 0.71 | HMGCR (0.60) | — | |
| SCHEMBL9872409 | 0.71 | HMGCR (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997837-A | Enzyme inhibitors | WARNER-LAMBERT COMPANY (US) | 1991-03-05 | — | — | US | disclosed |
| US-4906624-A | 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis | WARNER-LAMBERT COMPANY (US) | 1990-03-06 | — | — | US | disclosed |
| EP-0306929-A2 | 6-[[(Substituted)pyridin-3-YL]alkyl]-and alkenyl]-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis | WARNER-LAMBERT COMPANY (US) | 1989-03-15 | — | — | EP | disclosed |