Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 7/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9872443 | 0.75 | AKR1B1 (0.57) | AKR1B1GSK3BPRKCB | |
| SCHEMBL9870810 | 0.73 | AKR1B1 (0.67) | AKR1B1 | |
| SCHEMBL9870702 | 0.71 | AKR1B1 (0.54) | AKR1B1 | |
| SCHEMBL9870990 | 0.71 | AKR1B1 (0.62) | AKR1B1RORC | |
| SCHEMBL9870079 | 0.70 | AKR1B1 (0.36) | AKR1B1 | |
| SCHEMBL9871583 | 0.69 | AKR1B1 (0.61) | AKR1B1 | |
| SCHEMBL9870468 | 0.67 | AKR1B1 (0.50) | AKR1B1 | |
| SCHEMBL9203801 | 0.67 | AKR1B1 (0.61) | AKR1B1KMO | |
| SCHEMBL9870131 | 0.67 | AKR1B1 (0.67) | AKR1B1 | |
| SCHEMBL9872192 | 0.65 | AKR1B1 (0.54) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996204-A | Antidiabetic agents | PFIZER INC. (US) | 1991-02-26 | — | — | US | disclosed |