⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24662678 | 1.00 | — | — | |
| SCHEMBL24661958 | 1.00 | — | — | |
| SCHEMBL18909474 | 0.88 | DRD3 (0.44) | — | |
| SCHEMBL18513114 | 0.88 | DRD3 (0.44) | — | |
| SCHEMBL15998481 | 0.88 | DRD3 (0.44) | — | |
| SCHEMBL10035079 | 0.86 | HRH3 (0.43) | — | |
| SCHEMBL9871152 | 0.83 | L3MBTL3 (0.42) | — | |
| SCHEMBL27282016 | 0.83 | L3MBTL3 (0.42) | — | |
| SCHEMBL27282631 | 0.83 | L3MBTL3 (0.42) | — | |
| SCHEMBL6511612 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024081311-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2024-04-18 | — | — | WO | disclosed |
| WO-2024015864-A1 | CBL-B INHIBITORS AND ANTI-PD1/ANTI-PD-L1 FOR USE IN THE TREATMENT OF CANCER | HOTSPOT THERAPEUTICS, INC. (US) | 2024-01-18 | — | — | WO | disclosed |
| WO-2020156323-A1 | IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF | BETTA PHARMACEUTICALS CO., LTD (CN) | 2020-08-06 | — | — | WO | disclosed |
| WO-2017120194-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION (US) | 2017-07-13 | — | — | WO | disclosed |
| US-5063228-A | 4-(substitutedaminoethyl)-3,4-dihydro-2-alkylpyrimido[1,6-a]benzimidazol-1(2H)-ones as antiarrhythmic agents | A. H. ROBBINS COMPANY, INCORPORATED (US) | 1991-11-05 | — | — | US | disclosed |