SCHEMBL9870824

SCHEMBL9870824

FC(F)(F)C(Cl)(Cl)Oc1ccc(C(Cl)(Cl)Cl)cc1

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.37
TRPV1 Q8NER1 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31
KIF11 P52732 1/20 0.30
KDM4E B2RXH2 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10750142 0.89 MAPT (0.34) TSHRKDM4EMAPT
SCHEMBL11683258 0.82 MAPT (0.44) TSHRTRPV1KIF11KDM4EMAPT
SCHEMBL8649157 0.80 PPARA (0.42) TSHRCA1CA2CA9MAPT
SCHEMBL10641834 0.80 GAA (0.40) KDM4EMAPT
SCHEMBL8991041 0.77 TSHR (0.38) TSHRKIF11
SCHEMBL5176426 0.71 TSHR (0.48) TSHRMAPT
SCHEMBL9816151 0.69 TSHR (0.67) TSHR
SCHEMBL545084 0.69 TSHR (0.67) TSHR
SCHEMBL4475330 0.68 MAPT (0.44) TSHRTRPV1KIF11KDM4EMAPT
SCHEMBL1539075 0.68 TSHR (0.50) TSHRKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5047584-A Process for the preparation of pentahaloethoxy benzoyl halide compounds OCCIDENTAL CHEMICAL CORP. (US) 1991-09-10 US disclosed