Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.57 |
| ▸ | HTR2B | P41595 | 2/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11855492 | 0.87 | KDM2B (0.45) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL11864046 | 0.86 | L3MBTL1 (0.56) | KMT2A | |
| SCHEMBL11864468 | 0.85 | GFER (0.51) | HTR2AKCNH2TSHR | |
| SCHEMBL7383749 | 0.85 | DRD2 (0.56) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL11862797 | 0.85 | KDM2B (0.52) | — | |
| SCHEMBL9870507 | 0.84 | DRD2 (0.55) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL11864197 | 0.84 | KMT2A (0.49) | KMT2AHRH3HTTSMN1; SMN2SLC6A3 | |
| SCHEMBL11863400 | 0.83 | KMT2A (0.56) | KMT2AMEN1HTT | |
| SCHEMBL11865008 | 0.83 | KMT2A (0.45) | KMT2AMEN1 | |
| SCHEMBL9870458 | 0.83 | DRD2 (0.54) | DRD2HTR2AHTR2CHTR2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3962257-A | 3-PHENACYLPIPERIDINES | ELI LILLY AND COMPANY (US) | 1976-06-08 | — | — | US | claimed |
| US-5077288-A | Adrenergic, serotonin and histamine antagonist | ADIR ET COMPAGNIE (FR) | 1991-12-31 | — | — | US | disclosed |
| US-3962257-A | 3-PHENACYLPIPERIDINES | ELI LILLY AND COMPANY (US) | 1976-06-08 | — | — | US | disclosed |