Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9871117 | 1.00 | HTT (0.57) | HTTLMNANR1I2PGRCYP3A4 | |
| SCHEMBL9680043 | 0.91 | LMNA (0.70) | HTTLMNANR1I2PGRCYP3A4 | |
| SCHEMBL9680050 | 0.91 | LMNA (0.70) | HTTLMNANR1I2PGRCYP3A4 | |
| SCHEMBL9871872 | 0.88 | ADORA3 (0.67) | HTTLMNANR1I2PGRCYP3A4 | |
| SCHEMBL9871869 | 0.88 | ADORA3 (0.67) | HTTLMNANR1I2PGRCYP3A4 | |
| SCHEMBL9681553 | 0.82 | SLC6A2 (0.58) | HTTLMNANR1I2PGRCYP3A4 | |
| SCHEMBL9873204 | 0.82 | LMNA (0.57) | HTTLMNANR1I2PGRCYP3A4 | |
| SCHEMBL9873200 | 0.82 | LMNA (0.57) | HTTLMNANR1I2PGRCYP3A4 | |
| Hydrochloric Acid SCHEMBL9681547 | 0.81 | SLC6A2 (0.58) | HTTLMNANR1I2PGRCYP3A4 | |
| Hydrochloric Acid SCHEMBL9681550 | 0.81 | SLC6A2 (0.58) | HTTLMNANR1I2PGRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011848-A | Cardiovascular disorders, hypotensive agents | GLAXO, S.P.A. (IT) | 1991-04-30 | — | — | US | disclosed |
| US-4801599-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS | GLAXO S.P.A. (IT) | 1989-01-31 | — | — | US | disclosed |