Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aristolic Acid SCHEMBL9871957 | 0.83 | ALDH1A1 (0.67) | CDK2SMN1; SMN2ALDH1A1MAPTMEN1 | |
| Aristolic Acid SCHEMBL29655686 | 0.83 | ALDH1A1 (0.67) | CDK2SMN1; SMN2ALDH1A1MAPTMEN1 | |
| Aristolochic Acid Iii SCHEMBL30568104 | 0.79 | CDK2 (1.00) | CDK2AURKACDK1CDK4SMN1; SMN2 | |
| SCHEMBL24116503 | 0.77 | TP53 (0.50) | CDK2SMN1; SMN2ALDH1A1MAPTMEN1 | |
| Aristolamide SCHEMBL31261987 | 0.72 | MEN1 (0.58) | CDK2SMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL24116599 | 0.70 | NR4A1 (0.44) | CDK2SMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL29442138 | 0.67 | KDM4C (0.52) | CDK2ALDH1A1KDM4CDHODHKDM4E | |
| SCHEMBL340702 | 0.67 | KDM4C (0.52) | CDK2ALDH1A1KDM4CDHODHKDM4E | |
| SCHEMBL5391668 | 0.66 | CTNNB1 (0.55) | CDK2SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL29828929 | 0.66 | CTNNB1 (0.55) | CDK2SMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5024743-A | Prophylaxis and therapy of infectious diseases | MADAUS GMBH & CO. (DE) | 1991-06-18 | — | — | US | claimed |
| US-5024743-A | Prophylaxis and therapy of infectious diseases | MADAUS GMBH & CO. (DE) | 1991-06-18 | — | — | US | disclosed |
| US-4835178-A | Methylendioxyphenathrene and stilben derivatives, process for the preparation thereof, pharmaceutical compositions using these, and therapeutic applications | DR. MADAUS & CO. (DE) | 1989-05-30 | — | — | US | disclosed |