Aristolic Acid

Aristolic Acid

SCHEMBL29655686

COc1cccc2c1ccc1c(C(=O)O)cc3c(c12)OCO3

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.67
MAPT P10636 2/20 0.67
MEN1 O00255 1/20 0.67
CYP3A4 P08684 1/20 0.67
KMT2A Q03164 1/20 0.67
SMN1; SMN2 Q16637 1/20 0.67
CDK2 P24941 5/20 0.53
HPGD P15428 2/20 0.44
KDM4E B2RXH2 1/20 0.44
HSD17B10 Q99714 1/20 0.44
PDE10A Q9Y233 1/20 0.41
CYP2C9 P11712 1/20 0.41
HIF1A Q16665 1/20 0.41
CDC25B P30305 1/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
TP53 P04637 1/20 0.40
TSHR P16473 1/20 0.40
CYP19A1 P11511 1/20 0.39
NQO2 P16083 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aristolic Acid SCHEMBL9871957 1.00 ALDH1A1 (0.67) ALDH1A1MAPTMEN1CYP3A4KMT2A
Aristolamide SCHEMBL31261987 0.89 MEN1 (0.58) ALDH1A1MAPTMEN1CYP3A4KMT2A
SCHEMBL9871813 0.83 CDK2 (0.65) ALDH1A1MAPTMEN1CYP3A4KMT2A
Aristolochic Acid SCHEMBL30825061 0.81 ALDH1A1 (1.00) ALDH1A1MAPTMEN1CYP3A4KMT2A
Aristolochic Acid SCHEMBL166284 0.81 ALDH1A1 (1.00) ALDH1A1MAPTMEN1CYP3A4KMT2A
Aristolochic Acid SCHEMBL29367530 0.81 ALDH1A1 (1.00) ALDH1A1MAPTMEN1CYP3A4KMT2A
Aristolochic Acid SCHEMBL29518476 0.81 ALDH1A1 (1.00) ALDH1A1MAPTMEN1CYP3A4KMT2A
Aristolochic Acid SCHEMBL15535358 0.80 ALDH1A1 (0.98) ALDH1A1MAPTMEN1CYP3A4KMT2A
SCHEMBL9871373 0.77 CDK2 (0.51) ALDH1A1MAPTMEN1CYP3A4KMT2A
SCHEMBL29478504 0.74 ALDH1A1 (0.56) ALDH1A1MAPTMEN1CYP3A4KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113004401-B Anti-carpain monoclonal antibody and kit for detecting carpain 杭州隆基生物技术有限公司 2023-02-28 CN claimed
CN-115916431-A Bonding composition 阪东化学株式会社 2023-04-04 CN disclosed
CN-113004401-B Anti-carpain monoclonal antibody and kit for detecting carpain 杭州隆基生物技术有限公司 2023-02-28 CN disclosed
CN-115381900-A Traditional Chinese medicine composition for whitening and fading spots and preparation method thereof 西安航天基地美托邦医疗美容有限公司 2022-11-25 CN disclosed
CN-109195636-B End-blocked linear duplex DNA for non-viral gene transfer 马萨诸塞大学 2022-07-05 CN disclosed
CN-114617948-A Qiangli Madelia Doudai preparation and raw material composition, preparation method and application thereof 新疆维吾尔药业有限责任公司 2022-06-14 CN disclosed