SCHEMBL9872229

SCHEMBL9872229

COc1[c]ccc(N)c1I

nearest known ligand 0.31

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.31
ADRA2B P18089 1/20 0.31
PTGS1 P23219 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9548903 0.78
SCHEMBL28366984 0.77 ALDH1A1 (0.32) ALDH1A1ADRA2BPTGS1TDP1
SCHEMBL9833497 0.75 GAA (0.32) ALDH1A1ADRA2BPTGS1TDP1
SCHEMBL9874163 0.72
SCHEMBL5653014 0.70
SCHEMBL4843869 0.69 PDE4B (0.38) ALDH1A1ADRA2BPTGS1TDP1
SCHEMBL3180289 0.66 ALDH1A1 (0.32) ALDH1A1
SCHEMBL2971139 0.65
SCHEMBL11462369 0.63 ALDH1A1 (0.48) ALDH1A1ADRA2BPTGS1TDP1
SCHEMBL16974713 0.62 ALDH1A1 (0.33) ALDH1A1ADRA2BPTGS1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5017582-A Analgesics SANDOZ LTD. (CH) 1991-05-21 US disclosed
US-4910207-A Antipsychotic agent NOVARTIS AG (CH) 1990-03-20 US disclosed
US-4803199-A SEROTONIN ANTAGONIST, ANALGESIC ANTIARRHYTHMIC AGENTS NOVARTIS AG (CH) 1989-02-07 US disclosed
WO-1984000166-A1 BENZOIC ACID PIPERIDYL ESTER DERIVATIVES AND METHOD OF PRODUCTION AND UTILIZATION THEREOF SANDOZ AG (CH) 1984-01-19 WO disclosed