Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 8/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9875174 | 0.94 | AGTR2 (0.38) | AGTR1AGTR2TLR7KMT2AMAPK1 | |
| SCHEMBL9874922 | 0.94 | AGTR1 (0.41) | AGTR1AGTR2TLR7KMT2AMAPK1 | |
| SCHEMBL9873513 | 0.90 | TLR7 (0.42) | AGTR1AGTR2TLR7KMT2AMAPK1 | |
| SCHEMBL9872666 | 0.88 | AGTR1 (0.39) | AGTR1AGTR2TLR7KMT2AMAPK1 | |
| SCHEMBL9873176 | 0.87 | TLR7 (0.40) | AGTR1AGTR2TLR7KMT2AMAPK1 | |
| SCHEMBL9871757 | 0.86 | AGTR1 (0.39) | AGTR1AGTR2TLR7KMT2AMAPK1 | |
| SCHEMBL9873713 | 0.85 | AGTR1 (0.40) | AGTR1AGTR2TLR7KMT2AMAPK1 | |
| SCHEMBL9872186 | 0.85 | AGTR1 (0.40) | AGTR1AGTR2TLR7KMT2AMAPK1 | |
| SCHEMBL9872780 | 0.85 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL9873587 | 0.85 | TLR7 (0.40) | AGTR1AGTR2TLR7KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019715-A1 | 1H-SUBSTITUTED-IMIDAZO[4,5-d]PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-12-26 | — | — | WO | disclosed |