Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9680043 | 0.83 | LMNA (0.70) | HTTLMNANR1I2PGRCYP3A4 | |
| SCHEMBL9680050 | 0.83 | LMNA (0.70) | HTTLMNANR1I2PGRCYP3A4 | |
| SCHEMBL9871117 | 0.78 | HTT (0.57) | HTTLMNANR1I2PGRCYP3A4 | |
| SCHEMBL9871126 | 0.78 | HTT (0.57) | HTTLMNANR1I2PGRCYP3A4 | |
| SCHEMBL9681553 | 0.77 | SLC6A2 (0.58) | HTTLMNANR1I2PGRCYP3A4 | |
| Hydrochloric Acid SCHEMBL9681547 | 0.76 | SLC6A2 (0.58) | HTTLMNANR1I2PGRCYP3A4 | |
| Hydrochloric Acid SCHEMBL9681550 | 0.76 | SLC6A2 (0.58) | HTTLMNANR1I2PGRCYP3A4 | |
| SCHEMBL5174853 | 0.75 | APP (0.55) | HTTLMNACYP3A4APPSMN1; SMN2 | |
| SCHEMBL19359034 | 0.73 | APP (0.62) | LMNAAPPSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7771761 | 0.73 | APP (0.62) | LMNAAPPSMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011848-A | Cardiovascular disorders, hypotensive agents | GLAXO, S.P.A. (IT) | 1991-04-30 | — | — | US | disclosed |