Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.65 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PRKCB | P05771 | 1/20 | 0.51 |
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | MARK3 | P27448 | 1/20 | 0.51 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.51 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559116 | 0.89 | ROCK2 (0.64) | ROCK2ROCK1CITPRKD3MAP4K4 | |
| SCHEMBL988281 | 0.86 | ROCK2 (0.61) | ROCK2ROCK1CITPRKD3MAP4K4 | |
| SCHEMBL6845275 | 0.86 | ROCK2 (0.47) | ROCK2ROCK1TYK2JAK2BRAF | |
| SCHEMBL6557961 | 0.84 | ROCK2 (0.68) | ROCK2ROCK1CITPRKD3MAP4K4 | |
| SCHEMBL6845268 | 0.80 | ROCK2 (0.42) | ROCK2ROCK1BRAF | |
| SCHEMBL1553353 | 0.79 | ROCK2 (1.00) | ROCK2ROCK1CITPRKD3MAP4K4 | |
| SCHEMBL1553349 | 0.79 | ROCK2 (1.00) | ROCK2ROCK1CITPRKD3MAP4K4 | |
| SCHEMBL1554113 | 0.79 | ROCK2 (1.00) | ROCK2ROCK1CITPRKD3MAP4K4 | |
| Hydrochloric Acid SCHEMBL1770829 | 0.78 | ROCK2 (1.00) | ROCK2ROCK1CITPRKD3MAP4K4 | |
| Hydrochloric Acid SCHEMBL6559174 | 0.78 | ROCK2 (1.00) | ROCK2ROCK1CITPRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |