Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6845265 | 0.83 | ROCK2 (0.46) | ROCK2ROCK1ACVRL1MAPKAPK2MGLL | |
| SCHEMBL987306 | 0.80 | ROCK2 (0.65) | ROCK2ROCK1BRAF | |
| SCHEMBL7872530 | 0.76 | ROCK2 (0.44) | ROCK2 | |
| SCHEMBL3559320 | 0.71 | RAB9A (0.50) | ROCK2ROCK1MAPKAPK2 | |
| SCHEMBL6559116 | 0.70 | ROCK2 (0.64) | ROCK2ROCK1MAPKAPK2BRAF | |
| SCHEMBL22159079 | 0.68 | ALDH1A1 (0.57) | — | |
| SCHEMBL28318549 | 0.68 | ALDH1A1 (0.52) | ROCK2ROCK1PARP14 | |
| SCHEMBL26186330 | 0.67 | MAPK10 (0.45) | MAPKAPK2 | |
| SCHEMBL6845262 | 0.67 | TRIM24 (0.49) | — | |
| SCHEMBL988281 | 0.66 | ROCK2 (0.61) | ROCK2ROCK1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |