Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | THPO | P40225 | 2/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11705882 | 0.82 | HTR7 (0.40) | DRD2HRH1HTR2CTP53CYP1A2 | |
| SCHEMBL11707106 | 0.82 | HTR7 (0.40) | DRD2HRH1HTR2CTP53CYP1A2 | |
| SCHEMBL8168724 | 0.82 | HRH1 (0.50) | DRD2HRH1HTR2CTP53CYP1A2 | |
| SCHEMBL11009156 | 0.82 | HTR2C (0.36) | DRD2HRH1HTR2CTP53CYP1A2 | |
| SCHEMBL11706143 | 0.82 | DRD2 (0.41) | DRD2HRH1HTR2CTP53CYP1A2 | |
| SCHEMBL8171297 | 0.82 | DRD2 (0.44) | DRD2HRH1HTR2CTP53CYP1A2 | |
| SCHEMBL11486519 | 0.80 | DRD2 (0.36) | DRD2HRH1HTR2CTP53CYP1A2 | |
| SCHEMBL11479312 | 0.80 | DRD2 (0.42) | DRD2HRH1HTR2CTP53CYP1A2 | |
| SCHEMBL11703879 | 0.78 | CYBB (0.44) | DRD2HRH1HTR2CTP53CYP1A2 | |
| SCHEMBL11013573 | 0.78 | NPSR1 (0.40) | DRD2HRH1HTR2CTP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006664-A | Reacting 10,11-dihydro-10-hydroxybenz b,f!thiepin with an aminoalkylthiol in presence of boron trifluoride etherate and solvent; antidepressant, analgesic, anticonvulsant | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-04-09 | — | — | US | claimed |
| US-5006664-A | Reacting 10,11-dihydro-10-hydroxybenz b,f!thiepin with an aminoalkylthiol in presence of boron trifluoride etherate and solvent; antidepressant, analgesic, anticonvulsant | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4775672-A | ANTIDEPRESSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | disclosed |
| US-4775683-A | ANTIDEPRESSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | disclosed |
| US-4775682-A | ANALGESICS, ANTIPRESSANTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | disclosed |
| US-4771069-A | ANTIDEPRESSANTS, ANALGESICS, ANTICONVULSANTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-09-13 | — | — | US | disclosed |
| US-4766143-A | ANTIDEPRESSANTS, ANTICONVULSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-08-23 | — | — | US | disclosed |
| US-4668695-A | ANTIDEPRESSANTS, ANALGESICS ANTICONVULSANTS | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1987-05-26 | — | — | US | disclosed |