Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 4/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873127 | 0.92 | AGTR2 (0.38) | AGTR2AGTR1 | |
| SCHEMBL9874148 | 0.85 | AGTR2 (0.36) | AGTR2AGTR1 | |
| SCHEMBL9874176 | 0.79 | AGTR1 (0.31) | AGTR2AGTR1 | |
| SCHEMBL9872519 | 0.79 | AGTR1 (0.51) | AGTR2AGTR1 | |
| SCHEMBL9873359 | 0.78 | AGTR2 (0.39) | AGTR2AGTR1 | |
| SCHEMBL9873002 | 0.77 | AGTR1 (0.38) | AGTR2AGTR1 | |
| SCHEMBL9874500 | 0.77 | AGTR1 (0.38) | AGTR2AGTR1 | |
| SCHEMBL9708515 | 0.77 | PDE1A (0.42) | MEN1KMT2A | |
| SCHEMBL9707847 | 0.77 | PDE5A (0.45) | — | |
| SCHEMBL9872051 | 0.76 | AGTR1 (0.38) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019715-A1 | 1H-SUBSTITUTED-IMIDAZO[4,5-d]PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-12-26 | — | — | WO | disclosed |