Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873245 | 0.93 | AGTR1 (0.34) | PDE3APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9874555 | 0.91 | AGTR1 (0.37) | PDE3AAGTR1AGTR2ABCB11EGFR | |
| SCHEMBL9873542 | 0.90 | USP1 (0.33) | PDE3AAGTR1AGTR2ABCB11EGFR | |
| SCHEMBL9874827 | 0.89 | AGTR1 (0.37) | PDE3APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9872232 | 0.88 | AGTR1 (0.33) | PDE3AAGTR1AGTR2ABCB11EGFR | |
| SCHEMBL9872584 | 0.88 | TP53 (0.35) | AGTR1AGTR2PPARG | |
| SCHEMBL9874218 | 0.87 | AGTR1 (0.34) | AGTR1AGTR2 | |
| SCHEMBL9873966 | 0.85 | AGTR1 (0.33) | AGTR1AGTR2PPARG | |
| SCHEMBL9872149 | 0.85 | AGTR1 (0.36) | PDE3APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9873410 | 0.84 | AGTR1 (0.50) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019715-A1 | 1H-SUBSTITUTED-IMIDAZO[4,5-d]PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-12-26 | — | — | WO | disclosed |