Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300764 | 0.85 | TAAR1 (0.58) | TAAR1CYP2C19HIF1AMAPTKMT2A | |
| Acetic Acid SCHEMBL6327506 | 0.82 | TAAR1 (0.50) | TAAR1CYP2C19HIF1AMAPTKMT2A | |
| Nitric Acid SCHEMBL9874831 | 0.81 | MEN1 (0.44) | CYP2C19HIF1AKMT2APDK1PDK3 | |
| Nitric Acid SCHEMBL9491655 | 0.79 | ESR1 (0.56) | CYP2C19HIF1AMAPTKMT2AALDH1A1 | |
| Nitric Acid SCHEMBL9803865 | 0.78 | CYP2C9 (0.41) | CYP2C19HIF1AGSRKMT2AALDH1A1 | |
| SCHEMBL11444394 | 0.77 | CYP2C19 (0.41) | TAAR1CYP2C19HIF1AGSRMAPT | |
| SCHEMBL6565904 | 0.77 | CYP2C19 (0.46) | TAAR1CYP2C19HIF1AMAPTKMT2A | |
| SCHEMBL428785 | 0.77 | ALDH1A1 (0.49) | MAPTPDK1PDK3PDK4ALDH1A1 | |
| SCHEMBL10950133 | 0.76 | TAAR1 (0.48) | TAAR1CYP2C19HIF1AMAPTKMT2A | |
| Butyric Acid SCHEMBL28532337 | 0.74 | CYP2C19 (0.47) | TAAR1CYP2C19HIF1AMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | disclosed |
| EP-0359335-A2 | Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance | CEDONA PHARMACEUTICALS B.V. (NL) | 1990-03-21 | — | — | EP | disclosed |