Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | CCR9 | P51686 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1807039 | 0.87 | MEN1 (0.56) | MEN1KMT2AGRIN2DGRIN3BGRIN1 | |
| Nitric Acid SCHEMBL9873795 | 0.81 | TAAR1 (0.45) | KMT2APDK1PDK3PDK4CYP1A2 | |
| SCHEMBL428785 | 0.78 | ALDH1A1 (0.49) | PDK1PDK3PDK4POLBTSHR | |
| 1,4-Dichlorobenzene SCHEMBL29002852 | 0.76 | FBP1 (0.52) | MEN1KMT2ACYP1A2CYP2C19FBP1 | |
| SCHEMBL4593380 | 0.76 | CNR1 (0.48) | MEN1KMT2APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL8957402 | 0.74 | GRIN2D (0.49) | MEN1KMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL27357482 | 0.72 | KMT2A (0.54) | MEN1KMT2APOLBNPSR1MIF | |
| SCHEMBL11319289 | 0.70 | MEN1 (0.56) | MEN1KMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL7039179 | 0.70 | MEN1 (0.50) | MEN1KMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL10879927 | 0.69 | LMNA (0.52) | NPC1RAB9ASMN1; SMN2TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | disclosed |
| EP-0359335-A2 | Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance | CEDONA PHARMACEUTICALS B.V. (NL) | 1990-03-21 | — | — | EP | disclosed |