Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SCN4A | P35499 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.42 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873553 | 0.85 | SMN1; SMN2 (0.47) | CYP1A2CYP2C9CYP2C19RIPK1RAB9A | |
| SCHEMBL9872284 | 0.80 | RAB9A (0.46) | CYP1A2CYP2C9CYP2C19RAB9ANPC1 | |
| SCHEMBL9872449 | 0.76 | MAPK1 (0.45) | CYP1A2CYP2C9CYP2C19RAB9ASMN1; SMN2 | |
| SCHEMBL26077550 | 0.70 | RAB9A (0.54) | CYP1A2CYP2C9CYP2C19RIPK1RAB9A | |
| SCHEMBL30051979 | 0.70 | MAPT (0.67) | CYP1A2CYP2C9CYP2C19RAB9ASMN1; SMN2 | |
| SCHEMBL22589844 | 0.69 | HDAC6 (0.60) | CYP1A2CYP2C9CYP2C19RAB9ANPC1 | |
| SCHEMBL9133647 | 0.68 | AURKA (0.57) | RIPK1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4405590 | 0.67 | RAB9A (0.62) | RAB9ANPC1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL18366936 | 0.67 | SMN1; SMN2 (0.52) | CYP1A2RIPK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6277857 | 0.67 | MEN1 (0.65) | SMN1; SMN2GAAALDH1A1SCN4ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5073565-A | Atherosclerosis, anticholesterol | WARNER-LAMBERT COMPANY (US) | 1991-12-17 | — | — | US | disclosed |
| WO-1991017150-A1 | TETRAZOLE UREA AND THIOUREA ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1991-11-14 | — | — | WO | disclosed |