Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 3/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4556683 | 0.87 | SCN1A (0.57) | SCN1ASCN2ASCN3ASLC6A4SLC6A3 | |
| SCHEMBL9874449 | 0.77 | PTGS1 (0.49) | GSRSCN1ASCN2ASCN3ASLC6A4 | |
| SCHEMBL14160113 | 0.77 | SCN1A (0.51) | SCN1ASCN2ASCN3ASLC6A4SLC6A3 | |
| SCHEMBL5411041 | 0.77 | SCN1A (0.50) | SCN1ASCN2ASCN3ASLC6A4SLC6A3 | |
| SCHEMBL4667514 | 0.76 | SCN1A (0.53) | SCN1ASCN2ASCN3ASLC6A4SLC6A3 | |
| SCHEMBL4669215 | 0.75 | ACP3 (0.50) | SCN1ASCN2ASCN3ASLC6A4SLC6A3 | |
| SCHEMBL4667564 | 0.74 | SCN1A (0.65) | SCN1ASCN2ASCN3ASLC6A4SLC6A3 | |
| SCHEMBL4669156 | 0.74 | SCN1A (0.52) | SCN1ASCN2ASCN3ASLC6A4SLC6A3 | |
| Nitric Acid SCHEMBL9875712 | 0.74 | GSR (0.49) | GSRHTR2AHRH1MEN1KMT2A | |
| Nitric Acid SCHEMBL9874855 | 0.74 | GSR (0.56) | GSRLMNAHTTCYP2D6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | disclosed |
| EP-0359335-A2 | Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance | CEDONA PHARMACEUTICALS B.V. (NL) | 1990-03-21 | — | — | EP | disclosed |