Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 6/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 5/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL128570 | 0.85 | HRH1 (0.56) | CNR1CNR2HRH1TRPA1MTNR1A | |
| Nitric Acid SCHEMBL9874855 | 0.83 | GSR (0.56) | GSRCNR1CNR2TRPA1HTR2A | |
| Ammonia Solution, Strong SCHEMBL28849214 | 0.83 | HRH1 (0.54) | CNR1CNR2HRH1TRPA1MTNR1A | |
| SCHEMBL30576722 | 0.78 | CNR1 (0.54) | CNR1CNR2NPC1MEN1KMT2A | |
| SCHEMBL11130514 | 0.78 | GSR (0.47) | GSRCNR1CNR2TRPA1NPC1 | |
| Nitric Acid SCHEMBL9803283 | 0.76 | GSR (0.53) | GSRNPC1MEN1KMT2A | |
| SCHEMBL5604418 | 0.75 | LMNA (0.53) | CNR1CNR2HRH1TRPA1MTNR1A | |
| SCHEMBL5490855 | 0.75 | CHRNB2 (0.57) | HRH1TRPA1HTR2A | |
| Nitric Acid SCHEMBL9872245 | 0.74 | GSR (0.51) | GSRTRPA1NPC1MEN1KMT2A | |
| SCHEMBL6011425 | 0.74 | CCR2 (0.49) | EPHX2CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | claimed |
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | disclosed |
| EP-0359335-A2 | Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance | CEDONA PHARMACEUTICALS B.V. (NL) | 1990-03-21 | — | — | EP | disclosed |