Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 3/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15617595 | 0.84 | CNR1 (0.56) | GSRCNR1CNR2ALDH1A1LMNA | |
| Nitric Acid SCHEMBL9803283 | 0.83 | GSR (0.53) | GSRNPC1ALDH1A1LMNAMEN1 | |
| Nitric Acid SCHEMBL9875712 | 0.83 | GSR (0.49) | GSRNPC1ADAM17CNR1CNR2 | |
| SCHEMBL193835 | 0.83 | HTR2A (0.52) | GSRTRPA1HTR2ATAAR1LMNA | |
| Nitric Acid SCHEMBL9872245 | 0.82 | GSR (0.51) | GSRNPC1ADAM17TRPA1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6251948 | 0.81 | HTR2A (0.50) | GSRTRPA1HTR2ATAAR1LMNA | |
| Ammonia Solution, Strong SCHEMBL28352255 | 0.81 | HTR2A (0.50) | GSRTRPA1HTR2ATAAR1LMNA | |
| SCHEMBL16396156 | 0.80 | ACP3 (0.59) | ALDH1A1LMNAMEN1KMT2AACP3 | |
| Nitric Acid SCHEMBL9838314 | 0.77 | ALDH1A1 (0.47) | GSRALDH1A1HTR2ALMNAMEN1 | |
| Acetic Acid SCHEMBL28538311 | 0.77 | MTNR1A (0.52) | TRPA1HTR2ALMNAKMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | disclosed |
| EP-0359335-A2 | Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance | CEDONA PHARMACEUTICALS B.V. (NL) | 1990-03-21 | — | — | EP | disclosed |