SCHEMBL9874653 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	AGTR1	P30556	8/20	0.40

▸	AGTR2	P50052	7/20	0.40

▸	KMT2A	Q03164	2/20	0.35

▸	KDM4E	B2RXH2	1/20	0.35

▸	MEN1	O00255	1/20	0.35

▸	ALDH1A1	P00352	1/20	0.35

▸	LMNA	P02545	1/20	0.35

▸	TLR7	Q9NYK1	1/20	0.35

▸	FFAR4	Q5NUL3	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL9874510	0.94	AGTR2 (0.38)	AGTR1AGTR2KMT2AKDM4EMEN1
SCHEMBL9874853	0.89	AGTR1 (0.40)	AGTR1AGTR2KMT2AKDM4EMEN1
SCHEMBL9873083	0.88	AGTR1 (0.39)	AGTR1AGTR2KMT2AKDM4EMEN1
SCHEMBL9873455	0.88	AGTR1 (0.39)	AGTR1AGTR2KMT2AKDM4EMEN1
SCHEMBL9874003	0.87	PPARG (0.34)	AGTR1AGTR2KMT2AKDM4EMEN1
SCHEMBL9872187	0.87	AGTR1 (0.39)	AGTR1AGTR2KMT2AKDM4EMEN1
SCHEMBL9872972	0.87	AGTR1 (0.39)	AGTR1AGTR2KMT2AKDM4EMEN1
SCHEMBL9871040	0.85	AGTR1 (0.46)	AGTR1AGTR2
SCHEMBL9874765	0.85	AGTR1 (0.35)	AGTR1AGTR2
SCHEMBL9871777	0.85	AGTR1 (0.38)	AGTR1AGTR2KMT2AKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-1991019715-A1	1H-SUBSTITUTED-IMIDAZO[4,5-d]PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS	G.D. SEARLE & CO. (US)	1991-12-26	—	—	WO	disclosed