SCHEMBL9874752

SCHEMBL9874752

CC(C(=O)O)n1c(Br)c(CCNS(=O)(=O)c2ccc(F)cc2)c2ccccc21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.47
CYP19A1 P11511 5/20 0.46
HDAC3 O15379 7/20 0.46
HDAC4 P56524 7/20 0.46
HDAC1 Q13547 7/20 0.46
HDAC7 Q8WUI4 7/20 0.46
HDAC2 Q92769 7/20 0.46
HDAC10 Q969S8 7/20 0.46
HDAC11 Q96DB2 7/20 0.46
HDAC8 Q9BY41 7/20 0.46
HDAC6 Q9UBN7 7/20 0.46
HDAC9 Q9UKV0 7/20 0.46
HDAC5 Q9UQL6 7/20 0.46
HTT P42858 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
PTGDR2 Q9Y5Y4 1/20 0.43
SGMS1 Q86VZ5 2/20 0.41
LMNA P02545 1/20 0.41
CYP1A2 P05177 1/20 0.41
POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9874784 0.93 HDAC3 (0.47) CYP19A1HDAC3HDAC4HDAC1HDAC7
SCHEMBL9873570 0.90 KCNA5 (0.47) CYP19A1HDAC3HDAC4HDAC1HDAC7
SCHEMBL9362961 0.80 HDAC1 (0.52) TAAR1HDAC3HDAC4HDAC1HDAC7
SCHEMBL9874573 0.80 CYP19A1 (0.47) CYP19A1HDAC3HDAC4HDAC1HDAC7
SCHEMBL9359152 0.79 PTGDR2 (0.51) TAAR1CYP19A1HDAC3HDAC4HDAC1
SCHEMBL9814947 0.73 TBXAS1 (0.56) TAAR1HDAC3HDAC4HDAC1HDAC7
SCHEMBL9358770 0.71 HDAC3 (0.52) CYP19A1HDAC3HDAC4HDAC1HDAC7
SCHEMBL9874780 0.71 FABP3 (0.49) CYP19A1HDAC3HDAC4HDAC1HDAC7
SCHEMBL9363311 0.71 KCNA5 (0.56) CYP19A1HDAC3HDAC4HDAC1HDAC7
SCHEMBL9362957 0.69 KCNA5 (0.54) TAAR1HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5015657-A Anticoagulants BAYER AKTIENGESELLSCHAFT (DE) 1991-05-14 US claimed
US-5015657-A Anticoagulants BAYER AKTIENGESELLSCHAFT (DE) 1991-05-14 US disclosed