Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9875732 | 1.00 | ALDH1A1 (0.46) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL9875280 | 1.00 | ALDH1A1 (0.46) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL16229100 | 0.81 | HSD11B1 (0.44) | ALDH1A1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL9873869 | 0.79 | HSD11B1 (0.48) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL9873866 | 0.79 | HSD11B1 (0.48) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL8497717 | 0.78 | MEN1 (0.42) | KMT2AMEN1CYP2C9CYP2C19MAPT | |
| SCHEMBL9094767 | 0.78 | MEN1 (0.42) | KMT2AMEN1CYP2C9CYP2C19MAPT | |
| SCHEMBL1066268 | 0.78 | TSHR (0.42) | KMT2AMEN1CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL13390625 | 0.78 | MEN1 (0.41) | ALDH1A1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL10790279 | 0.78 | TSHR (0.40) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5043456-A | 6-oxa and thiabicyclo [3.1.0.] compounds | SHIONOGI & CO., LTD. (JP) | 1991-08-27 | — | — | US | disclosed |
| US-5043451-A | Bicyclo (2.2.1.) hept-exo-2-yl and bicyclo (2.2.2.) oct-endo-2-yl compounds | SHIONOGI & CO., LTD. (JP) | 1991-08-27 | — | — | US | disclosed |
| US-5041635-A | 5(Z)-7-(endo-3-benzenesulfonamidobicyclo[2.2.1]hept-exo-2-yl)-5-heptenoic acid, sodium salt | SHIONOGI & CO., LTD. (JP) | 1991-08-20 | — | — | US | disclosed |
| EP-0226346-B1 | BICYCLIC SULFONAMIDE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4976891-A | Antithrombotic, antivasoconstricting, antibronchoconstricting | SHIONOGI & CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| US-4960909-A | ANTICOAGULANTS; VASODILATORS; BRONCHODILATOR AGENTS | SHIONOGI & CO., LTD. (JP) | 1990-10-02 | — | — | US | disclosed |
| US-4861913-A | Bicyclic sulfonamide derivatives | SHIONOGI & CO., LTD. (JP) | 1989-08-29 | — | — | US | disclosed |
| EP-0226346-A1 | Bicyclic sulfonamide derivatives | SHIONOGI & CO., LTD. (JP) | 1987-06-24 | — | — | EP | disclosed |