SCHEMBL9875620

SCHEMBL9875620

O=C1CCCc2nc3ccccc3c(NCc3ccccc3C(F)(F)F)c21

nearest known ligand 0.63

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.46
MEN1 O00255 2/20 0.46
HTT P42858 2/20 0.46
KMT2A Q03164 2/20 0.46
BCHE P06276 5/20 0.42
ACHE P22303 5/20 0.42
BACE1 P56817 1/20 0.42
LMNA P02545 1/20 0.42
ACP1 P24666 1/20 0.42
CYP3A4 P08684 1/20 0.42
CD38 P28907 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9874424 0.89 ACHE (0.42) KDM4EBCHEACHECYP3A4CD38
SCHEMBL9874955 0.86 KDM4E (0.48) KDM4EMEN1HTTKMT2ABCHE
SCHEMBL9874947 0.84 KDM4E (0.51) KDM4EMEN1HTTKMT2ABCHE
SCHEMBL9874258 0.84 KDM4E (0.48) KDM4EMEN1HTTKMT2ABCHE
SCHEMBL9875622 0.83 KDM4E (0.54) KDM4EMEN1HTTKMT2ABCHE
SCHEMBL8984077 0.82 KMT2A (0.67) KDM4EMEN1HTTKMT2ABCHE
SCHEMBL9876195 0.81 CYP1A2 (0.51) KDM4EMEN1HTTKMT2ABCHE
SCHEMBL9875377 0.81 APP (0.53) KDM4EMEN1HTTKMT2ABCHE
SCHEMBL9875750 0.80 KDM4E (0.49) KDM4EMEN1HTTKMT2ABCHE
Water SCHEMBL9876033 0.80 CYP1A2 (0.50) KDM4EMEN1HTTKMT2ABCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4695573-A COGNITION ACTIVATORS HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1987-09-22 US claimed
EP-2681554-B1 BLOOD COLLECTION DEVICE CONTAINING LYSOPHOSPHOLIPASE INHIBITOR BECTON DICKINSON CO (US) 2017-08-09 EP disclosed
US-9459187-B2 Blood collection device containing lysophospholipase inhibitor BECTON, DICKINSON AND COMPANY (US) 2016-10-04 US disclosed
EP-2809289-A1 SAMPLE COLLECTION DEVICES WITH BLOOD STABILIZING AGENTS Becton, Dickinson and Company (US) 2014-12-10 EP disclosed
US-20140030754-A1 BLOOD COLLECTION DEVICE CONTAINING LYSOPHOSPHOLIPASE INHIBITOR BECTON, DICKINSON AND COMPANY (US) 2014-01-30 US disclosed
US-20130209985-A1 SAMPLE COLLECTION DEVICES WITH BLOOD STABILIZING AGENTS BECTON, DICKINSON AND COMPANY 2013-08-15 US disclosed
WO-2013116702-A1 SAMPLE COLLECTION DEVICES WITH BLOOD STABILIZING AGENTS BECTON, DICKINSON AND COMPANY (US) 2013-08-08 WO disclosed
EP-0179383-B1 9-AMINO-1,2,3,4-TETRAHYDROACRIDIN-1-OL AND RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1991-05-29 EP disclosed
US-4839364-A ALZHEIMER*S DISEASE; CHOLINESTERASE INHIBITORS HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1989-06-13 US disclosed
US-4835275-A Method of preparing 9-amino-1,2,3,4,-tetrahydroacridin-1-ones and related compounds HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1989-05-30 US disclosed
US-4754050-A COGNITION ACTIVATORS HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1988-06-28 US disclosed
US-4695573-A COGNITION ACTIVATORS HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1987-09-22 US disclosed
US-4631286-A MEMORY ENHANCERS HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1986-12-23 US disclosed
EP-0179383-A2 9-Amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1986-04-30 EP disclosed