Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718479 | 0.88 | KDM4E (0.64) | KMT2AKDM4ELMNAL3MBTL1MEN1 | |
| SCHEMBL6627628 | 0.86 | KDM4E (0.64) | KMT2AKDM4ELMNAL3MBTL1MEN1 | |
| SCHEMBL14074899 | 0.84 | KDM4E (0.62) | KMT2AKDM4ELMNAL3MBTL1MEN1 | |
| SCHEMBL20482668 | 0.82 | L3MBTL1 (0.49) | KMT2AKDM4ELMNAL3MBTL1MEN1 | |
| SCHEMBL6311126 | 0.82 | POLB (0.54) | KMT2AKDM4ELMNAMEN1NPC1 | |
| SCHEMBL13887157 | 0.80 | KMT2A (0.73) | KMT2AKDM4ELMNAL3MBTL1MEN1 | |
| SCHEMBL8357628 | 0.80 | KMT2A (0.51) | KMT2AKDM4ELMNAL3MBTL1MEN1 | |
| SCHEMBL20482685 | 0.80 | L3MBTL1 (0.45) | KMT2AKDM4ELMNAL3MBTL1MEN1 | |
| SCHEMBL6627953 | 0.79 | ALDH1A1 (0.70) | KMT2AKDM4ELMNAL3MBTL1MEN1 | |
| SCHEMBL9875164 | 0.78 | KDM4E (0.50) | KMT2AKDM4ELMNAMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049696-A | Enzyme inhibitors | MERCK & CO., INC. (US) | 1991-09-17 | — | — | US | disclosed |
| US-4847306-A | ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0245004-A2 | Antihypercholesterolemic compounds | MERCK & CO. INC. (US) | 1987-11-11 | — | — | EP | disclosed |