SCHEMBL9876085

CNC(=O)[C@H](Cc1ccc(OC)cc1)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(C)N(C(=O)OC(C)(C)C)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	REN	P00797	20/20	0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL9874799	0.95	REN (0.49)	REN
SCHEMBL9876329	0.94	REN (0.46)	REN
SCHEMBL10630729	0.94	REN (0.46)	REN
SCHEMBL9876290	0.92	REN (0.46)	REN
SCHEMBL9876391	0.91	REN (0.43)	REN
SCHEMBL9876258	0.90	REN (0.44)	REN
SCHEMBL9876376	0.90	REN (0.45)	REN
SCHEMBL10459449	0.84	REN (0.44)	REN
SCHEMBL10767582	0.84	REN (0.40)	REN
SCHEMBL9876303	0.82	REN (0.64)	REN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-4992562-A	Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues	PFIZER INC. (US)	1991-02-12	—	—	US	disclosed
US-4948913-A	Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues	PFIZER INC. (US)	1990-08-14	—	—	US	disclosed
US-4729985-A	Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues	PFIZER INC. (US)	1988-03-08	—	—	US	disclosed
EP-0212903-A2	Polypeptide derivatives containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues	PFIZER INC. (US)	1987-03-04	—	—	EP	disclosed