Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | MC3R | P41968 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876221 | 1.00 | GAA (0.60) | GAASMN1; SMN2NPC1RAB9AHSP90AA1 | |
| SCHEMBL940555 | 0.79 | HSP90AA1 (0.58) | GAASMN1; SMN2NPC1RAB9AHSP90AA1 | |
| SCHEMBL940788 | 0.79 | HSP90AA1 (0.58) | GAASMN1; SMN2NPC1RAB9AHSP90AA1 | |
| SCHEMBL9768809 | 0.77 | LMNA (0.69) | GAASMN1; SMN2NPC1RAB9AHSP90AA1 | |
| SCHEMBL9768802 | 0.77 | LMNA (0.69) | GAASMN1; SMN2NPC1RAB9AHSP90AA1 | |
| SCHEMBL27895124 | 0.73 | HSP90AA1 (0.46) | GAASMN1; SMN2NPC1RAB9AHSP90AA1 | |
| SCHEMBL28402900 | 0.73 | HSP90AA1 (0.67) | GAASMN1; SMN2NPC1RAB9AHSP90AA1 | |
| SCHEMBL9876260 | 0.72 | GAA (0.38) | GAASMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL9876264 | 0.72 | GAA (0.38) | GAASMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL6748574 | 0.72 | KDM4E (0.53) | GAASMN1; SMN2NPC1RAB9AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049561-A | Anthelmintic acylhydrazones, method of use and compositions | THE UPJOHN COMPANY (US) | 1991-09-17 | — | — | US | claimed |
| EP-0370065-A1 | ANTHELMINTIC ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS | THE UPJOHN COMPANY (US) | 1990-05-30 | — | — | EP | claimed |
| WO-1989000992-A1 | ANTHELMINTIC ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS | THE UPJOHN COMPANY (US) | 1989-02-09 | — | — | WO | claimed |