Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PEPD | P12955 | 6/20 | 0.49 |
| ▸ | XPNPEP1 | Q9NQW7 | 4/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSH | P09668 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.37 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876344 | 1.00 | PEPD (0.49) | PEPDXPNPEP1RENLMNARAB9A | |
| SCHEMBL9876718 | 0.81 | REN (0.49) | PEPDREN | |
| SCHEMBL9876722 | 0.81 | REN (0.49) | PEPDREN | |
| SCHEMBL21536110 | 0.79 | PEPD (0.54) | PEPDXPNPEP1LMNARAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28286265 | 0.78 | PEPD (0.53) | PEPDXPNPEP1LMNARAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28286264 | 0.78 | PEPD (0.53) | PEPDXPNPEP1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL4067269 | 0.76 | DPP4 (0.59) | PEPDXPNPEP1RENLMNAMMP3 | |
| SCHEMBL7403908 | 0.76 | DPP4 (0.59) | PEPDXPNPEP1RENLMNAMMP3 | |
| SCHEMBL4067266 | 0.76 | DPP4 (0.59) | PEPDXPNPEP1RENLMNAMMP3 | |
| Hydrochloric Acid SCHEMBL7350214 | 0.75 | DPP4 (0.58) | PEPDXPNPEP1RENLMNAMMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992562-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4948913-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| US-4729985-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1988-03-08 | — | — | US | disclosed |
| EP-0212903-A2 | Polypeptide derivatives containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1987-03-04 | — | — | EP | disclosed |