Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 16/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
| ▸ | CTSD | P07339 | 2/20 | 0.40 |
| ▸ | CTSE | P14091 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | PEPD | P12955 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876718 | 1.00 | REN (0.49) | RENKLK5CTSDCTSEBACE1 | |
| SCHEMBL9876267 | 0.85 | KLK5 (0.41) | RENKLK5CTSDCTSEBACE1 | |
| SCHEMBL9876342 | 0.81 | PEPD (0.49) | RENPEPD | |
| SCHEMBL9876344 | 0.81 | PEPD (0.49) | RENPEPD | |
| SCHEMBL7358701 | 0.81 | REN (0.60) | REN | |
| SCHEMBL7281729 | 0.81 | REN (0.56) | RENCTSDCTSE | |
| SCHEMBL21536111 | 0.80 | CTSK (0.53) | KLK5PEPD | |
| SCHEMBL28286258 | 0.80 | CTSK (0.53) | KLK5PEPD | |
| SCHEMBL10669316 | 0.79 | REN (0.61) | RENCTSDCTSE | |
| SCHEMBL10675193 | 0.79 | REN (0.61) | RENCTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992562-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4948913-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| US-4729985-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1988-03-08 | — | — | US | disclosed |