SCHEMBL9876400

SCHEMBL9876400

COCC/C(CC1=CCCN(C)C1)=N\O

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 4/20 0.37
CHRM5 P08912 4/20 0.37
CHRM1 P11229 4/20 0.37
CHRM4 P08173 3/20 0.37
CHRM3 P20309 3/20 0.37
LMNA P02545 1/20 0.37
THRB P10828 1/20 0.37
BLM P54132 1/20 0.36
MCOLN3 Q8TDD5 1/20 0.36
CHRNB2 P17787 1/20 0.34
CHRNA4 P43681 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9876403 1.00 CHRM2 (0.37) CHRM2CHRM5CHRM1CHRM4CHRM3
SCHEMBL9502380 0.75 TSHR (0.35) CHRM1CHRNB2CHRNA4
SCHEMBL10741620 0.74 CHRNB2 (0.40) CHRM2CHRM5CHRM1CHRM4CHRM3
SCHEMBL10741609 0.74 CHRNB2 (0.40) CHRM2CHRM5CHRM1CHRM4CHRM3
SCHEMBL9875513 0.72
SCHEMBL6771063 0.70 TSHR (0.38) CHRM2CHRM5CHRM1CHRM4CHRM3
SCHEMBL6771065 0.70 TSHR (0.38) CHRM2CHRM5CHRM1CHRM4CHRM3
SCHEMBL9130174 0.70 CHRM2 (0.48) CHRM2CHRM5CHRM1CHRM4CHRM3
SCHEMBL9876095 0.69 BLM (0.49) CHRM2CHRM5CHRM1CHRM4CHRM3
SCHEMBL9876099 0.69 BLM (0.49) CHRM2CHRM5CHRM1CHRM4CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5073561-A N-substituted-pyridinyl oximes WARNER-LAMBERT COMPANY (US) 1991-12-17 US disclosed
US-4929734-A ANTIINFLAMMATORY AGENTS, ANTIDEPRESSANTS WARNER-LAMBERT COMPANY (US) 1990-05-29 US disclosed
US-4798841-A COGNITION ACTIVATORS, ANALGESICS WARNER-LAMBERT COMPANY (US) 1989-01-17 US disclosed
EP-0291673-A1 Tetrahydropyridine oximes, a process for their preparation and use thereof as cholinergic agents WARNER-LAMBERT COMPANY (US) 1988-11-23 EP disclosed
US-4710508-A ANALGESICS WARNER-LAMBERT COMPANY (US) 1987-12-01 US disclosed