SCHEMBL9876548

CC(C)C[C@H](C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]cn1)N(C(=O)OC(C)(C)C)C(=O)[C@@H](N)Cc1ccccc1)C(=O)NCCCCCNC(=O)OCc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	REN	P00797	20/20	0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL9875580	0.94	REN (0.53)	REN
SCHEMBL9876341	0.91	REN (0.54)	REN
SCHEMBL9876598	0.88	REN (0.52)	REN
SCHEMBL9876545	0.86	REN (0.59)	REN
SCHEMBL9876291	0.85	REN (0.47)	REN
SCHEMBL9874806	0.85	REN (0.47)	REN
SCHEMBL9876330	0.83	REN (0.45)	REN
SCHEMBL10630739	0.82	REN (0.45)	REN
SCHEMBL9876262	0.82	REN (0.45)	REN
SCHEMBL9876377	0.82	REN (0.43)	REN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-4992562-A	Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues	PFIZER INC. (US)	1991-02-12	—	—	US	disclosed
US-4948913-A	Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues	PFIZER INC. (US)	1990-08-14	—	—	US	disclosed
US-4729985-A	Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues	PFIZER INC. (US)	1988-03-08	—	—	US	disclosed
EP-0212903-A2	Polypeptide derivatives containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues	PFIZER INC. (US)	1987-03-04	—	—	EP	disclosed