Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.49 |
| ▸ | METAP2 | P50579 | 5/20 | 0.41 |
| ▸ | METAP1 | P53582 | 4/20 | 0.41 |
| ▸ | CCR1 | P32246 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27673744 | 1.00 | REN (0.49) | RENMETAP2METAP1CCR1ALDH1A1 | |
| SCHEMBL4066470 | 0.89 | REN (0.48) | RENMETAP2METAP1CCR1ALDH1A1 | |
| SCHEMBL4061718 | 0.89 | REN (0.48) | RENMETAP2METAP1CCR1ALDH1A1 | |
| SCHEMBL4065186 | 0.87 | REN (0.55) | RENMETAP2METAP1CCR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7360375 | 0.86 | REN (0.54) | RENMETAP2METAP1CCR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10676905 | 0.86 | REN (0.54) | RENMETAP2METAP1CCR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27673691 | 0.86 | REN (0.54) | RENMETAP2METAP1CCR1ALDH1A1 | |
| SCHEMBL7367047 | 0.84 | REN (0.55) | RENMETAP2METAP1CCR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9876283 | 0.82 | REN (0.54) | RENMETAP2METAP1CCR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27692376 | 0.82 | REN (0.54) | RENMETAP2METAP1CCR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992562-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4948913-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| US-4729985-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1988-03-08 | — | — | US | disclosed |