Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.55 |
| ▸ | CCR1 | P32246 | 5/20 | 0.50 |
| ▸ | METAP2 | P50579 | 4/20 | 0.44 |
| ▸ | METAP1 | P53582 | 3/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9876283 | 0.99 | REN (0.54) | RENCCR1METAP2METAP1MMP1 | |
| Hydrochloric Acid SCHEMBL27692376 | 0.99 | REN (0.54) | RENCCR1METAP2METAP1MMP1 | |
| SCHEMBL4065186 | 0.91 | REN (0.55) | RENCCR1METAP2METAP1ALDH1A1 | |
| SCHEMBL4067962 | 0.90 | REN (0.53) | RENCCR1METAP2METAP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7360375 | 0.89 | REN (0.54) | RENCCR1METAP2METAP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10676905 | 0.89 | REN (0.54) | RENCCR1METAP2METAP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27673691 | 0.89 | REN (0.54) | RENCCR1METAP2METAP1ALDH1A1 | |
| SCHEMBL7583549 | 0.86 | REN (0.41) | RENCCR1METAP2METAP1MMP1 | |
| SCHEMBL9684516 | 0.85 | REN (0.69) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL4073025 | 0.85 | REN (0.52) | RENCCR1METAP2METAP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1988003022-A1 | RELATIVELY LOW MOLECULAR WEIGHT POLYPEPTIDES AS RENIN INHIBITORS | PFIZER INC. (US) | 1988-05-05 | — | — | WO | disclosed |