8-Chloroadenosine

8-Chloroadenosine

SCHEMBL987731

Nc1ncnc2c1nc(Cl)n2[C@@H]1O[C@H](CO)C(O)C1O

nearest known ligand 0.78

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSPA8 P11142 5/20 0.78
HSPA5 P11021 3/20 0.78
RXFP1 Q9HBX9 1/20 0.71
GAPDH P04406 3/20 0.68
HSD17B10 Q99714 1/20 0.68
SMN1; SMN2 Q16637 2/20 0.67
LMNA P02545 1/20 0.67
TP53 P04637 1/20 0.67
HBB P68871 1/20 0.67
SLC28A2 O43868 4/20 0.66
ADK P55263 1/20 0.64
ADORA3 P0DMS8 2/20 0.63
DPP4 P27487 1/20 0.62
MEN1 O00255 1/20 0.62
SLC28A1 O00337 1/20 0.62
MAP3K7 O43318 1/20 0.62
MAPK1 P28482 1/20 0.62
ADORA2A P29274 1/20 0.62
ADORA2B P29275 1/20 0.62
ADORA1 P30542 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
8-Chloroadenosine SCHEMBL19680324 1.00 HSPA8 (0.78) HSPA8HSPA5RXFP1GAPDHHSD17B10
8-Chloroadenosine SCHEMBL26788558 1.00 HSPA8 (0.78) HSPA8HSPA5RXFP1GAPDHHSD17B10
8-Chloroadenosine SCHEMBL987728 1.00 HSPA8 (0.78) HSPA8HSPA5RXFP1GAPDHHSD17B10
8-Chloroadenosine SCHEMBL31064773 1.00 HSPA8 (0.78) HSPA8HSPA5RXFP1GAPDHHSD17B10
8-Chloroadenosine SCHEMBL19668313 0.94 HSPA8 (0.71) HSPA8HSPA5RXFP1GAPDHHSD17B10
8-Chloroadenosine SCHEMBL10531116 0.94 HSPA8 (0.71) HSPA8HSPA5RXFP1GAPDHHSD17B10
8-Chloroadenosine SCHEMBL19668314 0.94 HSPA8 (0.69) HSPA8HSPA5RXFP1GAPDHHSD17B10
8-Chloroadenosine SCHEMBL6275972 0.94 HSPA8 (0.69) HSPA8HSPA5RXFP1GAPDHHSD17B10
8-Chloroadenosine SCHEMBL9752393 0.91 HSPA8 (0.66) HSPA8HSPA5RXFP1GAPDHHSD17B10
SCHEMBL12946772 0.91 HSPA8 (0.64) HSPA8HSPA5RXFP1GAPDHHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 254 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4720329-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS HAVING A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSTIC METHOD SensID GmbH (DE) 2026-04-08 EP claimed
US-20250268993-A1 ALKALINE PHOSPHATE-BASED ONCOLOGY TREATMENTS THERIVA BIOLOGICS, INC. 2025-08-28 US claimed
US-12318434-B2 Alkaline phosphate-based oncology treatments THERIVA BIOLOGICS, INC. (US) 2025-06-03 US claimed
WO-2025024123-A1 NOVEL CITICOLINE DERIVATIVES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-01-30 WO claimed
WO-2024246014-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS HAVING A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSTIC METHOD SENSID GMBH (DE) 2024-12-05 WO claimed
EP-4467659-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS WITH A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSIS SensID GmbH (DE) 2024-11-27 EP claimed
CN-118217301-A Pharmaceutical composition containing 8-chloroadenosine and homoharringtonine for synergistic treatment of AML 宁波大学附属人民医院 2024-06-21 CN claimed
US-20230346820-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2 THE SCRIPPS RESEARCH INSTITUTE 2023-11-02 US claimed
US-20220202914-A1 ALKALINE PHOSPHATE-BASED ONCOLOGY TREATMENTS THERIVA BIOLOGICS, INC. 2022-06-30 US claimed
EP-3965805-A1 ALKALINE PHOSPHATE-BASED ONCOLOGY TREATMENTS Synthetic Biologics, Inc. (US) 2022-03-16 EP claimed
WO-2019062919-A1 METHOD FOR TREATING LEUKEMIA OBI PHARMA, INC. (CN) 2019-04-04 WO claimed
WO-2018127786-A1 COMPOSITIONS AND METHODS FOR DETERMINING A TREATMENT COURSE OF ACTION OSLO UNIVERSITETSSYKEHUS HF (NO) 2018-07-12 WO claimed
WO-2017207993-A1 CANCER TREATMENTS NUCANA BIOMED LIMITED (GB) 2017-12-07 WO claimed
US-20130183289-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML) BIOGEN IDEC MA INC (US) 2013-07-18 US claimed
EP-2200611-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML) Biogen Idec MA, Inc. (US) 2010-06-30 EP claimed
WO-2009038684-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML) BIOGEN IDEC MA INC. (US) 2009-03-26 WO claimed
WO-2005120521-A2 METHODS OF TREATING CANCER WITH 8-CHLORO-ADENOSINE SOPHERION THERAPEUTICS (US) 2005-12-22 WO claimed
US-6512004-B2 Activation of kinase THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2003-01-28 US claimed
US-20020142990-A1 Promoters of neural regeneration NIH-DEITR 2002-10-03 US claimed
US-20020006916-A1 Activation of kinase NIH-DEITR 2002-01-17 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230346820-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2 ACE2, SARS1, ACE HSPA8 2551/4885HSPA5 1509/4885RXFP1 3817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.